Activation of Interferon-Stimulated Genes following Varicella-Zoster Virus Infection in a Human iPSC-Derived Neuronal In Vitro Model Depends on Exogenous Interferon-αArticle Published on 2022-11-142023-05-31 Journal: Viruses [Category] 두창, 수두, 홍역, [키워드] antiviral response axonal infection innate immune response interferon-stimulated genes Interferon-α IPSC neuronal models neurons Varicella-zoster virus. [DOI] 10.3390/v14112517 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
Generation of Cytotoxic T Cells and Dysfunctional CD8 T Cells in Severe COVID-19 PatientsArticle Published on 2022-10-252023-07-10 Journal: Cells [Category] COVID19(2023년), [키워드] antiviral response COVID-19 cytotoxic factors. SARS-CoV-2 T-lymphocytes [DOI] 10.3390/cells11213359 PMC 바로가기
Vitamin D enhances type I IFN signaling in COVID-19 patientsArticle Published on 2022-10-222022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval adjusted hazard ratio Admission all-cause mortality antimicrobial peptide Antiviral Antiviral effect antiviral response collected COVID-19 infection COVID-19 patient ENhance Host host response IFN in vitro intensive care interferon investigated ISGs JAK-STAT signaling pathway lower risk modulate on type outcome patient survival patients PBMC protein level Regulatory saliva specimen SARS-CoV-2 SARS-COV-2 infection severe COVID-19 patient Signaling significantly higher treated treated patient treated patients Treatment Type I IFN untreated patient Vitamin D Whole blood [DOI] 10.1038/s41598-022-22307-9 PMC 바로가기
Interplay between demographic, clinical and polygenic risk factors for severe COVID-19Article Published on 2022-10-132022-11-15 Journal: International Journal of Epidemiology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 95% CI adjusted odds ratio Admission age antiviral response association co-morbidity conducted COVID-19 COVID-19 diagnosis Critical care death develop diagnosed with COVID-19 enrolment Epidemiology European Factor Factors General population genetic data genetic risk factor Genetic variant greater highest hospital Hospitalization identify IMPROVE individual interquartile range lowest median men morbidity obesity outcomes participant Pathway analysis Pathways Patient polygenic risk score polymorphism PRS reported risk risk factor risk prediction. severe COVID-19 single-nucleotide Smokers socio-demographic UK biobank was performed [DOI] 10.1093/ije/dyac137 PMC 바로가기
Social connection and gene regulation during the COVID-19 pandemic: Divergent patterns for online and in-person interactionArticle Published on 2022-10-012022-11-15 Journal: Psychoneuroendocrinology [Category] 치료제, [키워드] absence analyzed antibody production antiviral immunity antiviral response association blood sample characterized connection conserved COVID-19 COVID-19 pandemic CTRA disease risk down-regulation Effect eudaimonia examined experience Factors female Gene Expression Health healthy Immune cell immune system Interaction Linear model loneliness measure Multiple offset Online social interaction profile proinflammatory gene quantified question reduced Regulation RNA Social genomics. social interaction transcriptional response [DOI] 10.1016/j.psyneuen.2022.105885 PMC 바로가기
Matrix metalloproteinase 3 restricts viral infection by enhancing host antiviral immunityArticle Published on 2022-10-012023-06-24 Journal: Antiviral Research [Category] 신종인플루엔자, [키워드] antiviral response immune regulation Innate immunity matrix metalloproteinase virus. [DOI] 10.1016/j.antiviral.2022.105388 PMC 바로가기
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기
SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variantArticle Published on 2022-09-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] Activation analyzed antiviral response arising Beta Calu-3 cell calu-3 cells cellular circumvent comparable replication correlated COVID-19 infection Delta Effect epithelial Evolution genomic host cell human lung Immunity induce innate immune innate immune activation Innate immunity interferon interferon response ISG ISGs mRNA expression Mutation mutations omicron pandemic produced Replication replication efficiency SARS-CoV-2 SARS-CoV-2 variant signaling pathways STAT2 stimulated Transmission Treatment vaccination Vaccine variant variants variants of concern variants. variations Viral RNA virus virus replication while [DOI] 10.3389/fimmu.2022.1016108 PMC 바로가기
Correlation between Type I Interferon Associated Factors and COVID-19 SeverityArticle Published on 2022-09-192022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] acute respiratory syndrome Adaptive immune response Affect Antiviral antiviral response caused cells Chronic diseases conditions coronavirus COVID-19 COVID-19 severity declined dendritic cell dysfunction dysregulation early phase Factor Factors Frequency IFN IFN response IFN signature increased risk individual individual immune response inhibit magnitude Mild no symptoms Patient plasmacytoid dendritic cell plasmacytoid dendritic cell 1 Prevent produced producing promote response responsible risk risk factor SARS-CoV-2 severe coronavirus disease severe COVID-19 tissue damage Type type I Type I IFN type I IFNs type I interferon type I interferon. viral infection viral infections viral replication viruses [DOI] 10.3390/ijms231810968 PMC 바로가기